Description

HLA-B27 (Human Leukocyte Antigen B27) is a gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B27 is associated with several autoimmune diseases, particularly ankylosing spondylitis, a type of arthritis that primarily affects the spine.

PCR (Polymerase Chain Reaction) is a technique used to amplify a specific segment of DNA, allowing for the detection and analysis of genetic material. In the context of HLA-B27, PCR can be used to detect the presence or absence of the HLA-B27 gene in an individual’s DNA sample. This test is often used in the diagnosis of conditions like ankylosing spondylitis and other HLA-B27-associated autoimmune diseases.