Description

ANCA-PR3 (anti-neutrophil cytoplasmic antibodies against proteinase 3) is a type of antibody test used in the diagnosis of certain autoimmune diseases, particularly those involving small blood vessel inflammation (vasculitis), such as granulomatosis with polyangiitis (GPA, formerly known as Wegener’s granulomatosis).

The test is performed using enzyme immunoassay (EIA) techniques to detect the presence of antibodies directed against proteinase 3, which is an enzyme found in neutrophils (a type of white blood cell). Elevated levels of ANCA-PR3 antibodies in the blood can indicate the presence of GPA or other related autoimmune conditions.

This test is an important tool for clinicians in diagnosing and monitoring the progress of these diseases, as well as determining appropriate treatment strategies. However, it’s essential to interpret the results in the context of the patient’s clinical presentation and other diagnostic findings.